منابع مشابه
Mate and fuse: how yeast cells do it
Many cells are able to orient themselves in a non-uniform environment by responding to localized cues. This leads to a polarized cellular response, where the cell can either grow or move towards the cue source. Fungal haploid cells secrete pheromones to signal mating, and respond by growing a mating projection towards a potential mate. Upon contact of the two partner cells, these fuse to form a...
متن کاملTo fuse or not to fuse: how do checkpoint and DNA repair proteins maintain telomeres?
DNA damage checkpoint and DNA repair mechanisms play critical roles in the stable maintenance of genetic information. Various forms of DNA damage that arise inside cells due to common errors in normal cellular processes, such as DNA replication, or due to exposure to various DNA damaging agents, must be quickly detected and repaired by checkpoint signaling and repair factors. Telomeres, the nat...
متن کاملConserved eukaryotic fusogens can fuse viral envelopes to cells.
Caenorhabditis elegans proteins AFF-1 and EFF-1 [C. elegans fusion family (CeFF) proteins] are essential for developmental cell-to-cell fusion and can merge insect cells. To study the structure and function of AFF-1, we constructed vesicular stomatitis virus (VSV) displaying AFF-1 on the viral envelope, substituting the native fusogen VSV glycoprotein. Electron microscopy and tomography reveale...
متن کاملTo fuse or not to fuse: what is your purpose?
Since the dawn of time, or at least the dawn of recombinant DNA technology (which for many of today's scientists is the same thing), investigators have been cloning and expressing heterologous proteins in a variety of different cells for a variety of different reasons. These range from cell biological studies looking at protein-protein interactions, post-translational modifications, and regulat...
متن کاملDETAiLS FUSE System Architecture
The DETAiLS architecture design was motivated by two concerns: efficiency and modularity. This project involves processing very large corpora of very long full text documents, and investigating the use of potentially computationally intensive natural language, network and time series features over that corpora. As such, it was necessary to develop a robust architecture capable of handling both ...
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ژورنال
عنوان ژورنال: Journal of Cell Biology
سال: 2019
ISSN: 0021-9525,1540-8140
DOI: 10.1083/jcb.201901017